Table 1 Inclusion and exclusion criteria

Histologically proven PDAC.

Complete macroscopic resection (R0 or R1 resection).

Currently receiving or planned to receive adjuvant chemotherapy (exercise to begin at cycle 3).

Prior malignancy active within the previous 3 years other than locally curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the prostate, cervix, or breast.

ECOG performance status 0–1.

Deemed medically fit by treating team to participate in exercise programme.

At least 18 years of age.

Medical clearance by treating clinician.

Exclusion criteria

Macroscopically remaining tumour (R2 resection or TNM stage IV disease).

Congestive heart failure or recent serious cardiovascular event.

Uncontrolled diabetes or another uncontrolled metabolic disease

Unstable angina

Chest pain while undertaking physical activity.

Any other active secondary malignancies

Other psychological, social or medical condition, physical examination finding or a laboratory abnormality that the Investigator considers would make the patient a poor trial candidate or could interfere with protocol compliance or the interpretation of trial results.