Table 1 PICOS strategy for studies eligibility

Population

Triathletes

Non Triathletes

Intervention

Triathlon

Any other type of physical activity, exercise or sport

Comparator

Individuals who did not perform triathlon intervention

Individuals exposed to pharmacological interventions, with associated pathological or psychiatric conditions

Outcomes

Cytokines:

Pro and anti-inflammatory

Metabolic markers

Creatine Kinase (CK)

Free Fatty Acids

C-Reactive Protein (CRP)

Endothelial Growth Factor (EGF) Vascular Endothelial Growth Factor (VEGF)

Cortisol

Myostatin

Lactate dehydrogenase (LDH)

Any parameter not related to pro- and anti-inflammatory cytokines and metabolic parameters linked to physical effort through triathlon practice

Study design

Intervention studies

Animal’s studies, review’s, letter for editor, comments, case report.