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Table 4 Within-group estimates of change from baseline (cfb, 95% CI) and the according between-group estimated treatment differences (ETDs) at t3, t6, t12 and t24 months for the primary and secondary outcomes

From: Effectiveness of an 11-week exercise intervention for patients with hip or knee osteoarthritis: results of a quasi-experimental pragmatic trial

 

Control (CO)

n = 515

Hip Knee Training (HKT)

n = 515

Estimated treatment difference (ETD)

CO—HKT

p-value

Effect Size

Primary Outcomes

 WOMAC

  pain t3

0.21 (0.07; 0.35)

-0.25 (-0.39; -0.11)

0.47 (0.27–0.66)

 < 0.001

0.22

  function t3

0.32 (0.21; 0.44)

-0.05 (-0.06; 0.17)

0.27 (0.11–0.44)

 < 0.001

0.13

Secondary Outcomes

 WOMAC

  pain t6

0.15 (-0.07; 0.36)

-0.14 (-0.36; 0.07)

0.29 (0.08; 0.51)

0.008

0.13

  pain t12

0.11 (-0.11; 0.32)

-0.23 (-0.44; -0.01)

0.33 (0.12; 0.55)

0.003

0.15

  pain t24

0.20 (-0.01; 0.44)

-0.14 (-0.35; 0.08)

0.34 (0.12; 0.55)

0.002

0.16

  function t6

0.36 (0.17; 0.55)

0.14 (-0.05; 0.33)

0.22 (0.03; 0.41)

0.020

0.11

  function t12

0.39 (0.20; 0.58)

0.05 (-0.13; 0.24)

0.33 (0.14; 0.52)

0.001

0.16

  function t24

0.43 (0.24; 0.62)

0.14 (-0.05, 0.34)

0.29 (0.09; 0.48)

0.003

0.14

 Veterans Rand-12 (VR-12)

  Physical Component Score t3

-0.05 (-0.96; 0.85)

0.83 (-0.08; 1.73)

-0.88 (-1.80; 0.36)

0.060

0.10

  Physical Component Score t6

0.22 (-0.69; 1.12)

0.86 (-0.04; 1.77)

-0.65 (-1.57; 0.27)

0.167

0.08

  Physical Component Score t12

-0.02 (-0.92; 0.89)

1.39 (0.49; 2.30)

-1.41 (-2.33; -0.49)

0.003

0.17

  Physical Component Score t24

0.70 (-0.20; 1.61)

0.87 (-0.04; 1.78)

-0.17 (-1.09; 0.76)

0.726

0.02

  Mental Component Score t3

-0.26 (-1.39; 0.87)

0.71 (-0.42; 1.84)

-0.97 (-5.14; -0.52)

0.096

0.09

  Mental Component Score t6

-0.12 (-1.24; 1.01)

0.15 (-0.98; 1.29)

-0.27 (-5.00; -0.36)

0.645

0.02

  Mental Component Score t12

0.21 (-0.92; 1.34)

-0.37 (-1.50; 0.77)

0.58 (-6.47; -1.83)

0.326

-0.05

  Mental Component Score t24

-0.49 (-1.62; 0.64)

-0.53 (-1.66; 0.61)

0.04 (-5.23; -0.60)

0.945

0.00

 General self-efficacy scale (GSE)

  GSE t3

-0.00 (-0.06; 0.05)

0.00 (-0.05; 0.06)

-0.00 (-0.06; 0.05)

0.857

0.00

  GSE t6

-0.02 (-0.07; 0.04)

0.01 (-0.05; 0.06)

-0.03 (-0.08; 0.03)

0.338

0.05

  GSE t12

-0.04 (-0.09; 0.02)

-0.01 (-0.06; 0.05)

-0.03 (-0.08; 0.02)

0.268

0.05

  GSE t24

-0.03 (-0.08; 0.03)

0.02 (-0.04; 0.07)

-0.04 (-0.10; 0.01)

0.104

0.07

  1. Linear Mixed Models (Time, Treatment, Time*Treatment, PS Propensity Score), WOMAC (0–10, best to worst): logarithmic estimates back-transformed to original scale, Veterans Rand-12 (VR-12, worst to best) of which the Physical component score (PCS90) and the Mental Component Score (MCS90) were calculated with values of 50 indicating the mean American Norm 1990, General Self-efficacy (GSE,1–4, worst to best). Scales best to worst (WOMAC): positive estimated treatment difference indicate benefit for HKT. Scales worst to best (VR-12, GSE): negative estimated treatment difference indicate benefit for HKT. P-values for time*treatment interaction of the LMMs. Significance in bold is set at alpha = .0025 to account for post-hoc testing with respect to the two primary outcomes. For secondary outcomes alpha = 0.05 without claiming confirmatory interpretation of p-values. Positive effect sizes indicate benefit for HKT versus CO
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BMC Sports Science, Medicine and Rehabilitation

ISSN: 2052-1847

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