Task-oriented exercise effects on walking and corticospinal excitability in multiple sclerosis: protocol for a randomized controlled trial

Table 2 Schedule of study enrolment, intervention and assessments

	Study period
	Enrollment	Allocation	Baseline A_x	Intervention	Post A_x	Retention A_x
Time point		Week 0	Week 0	Weeks 1–12	Week 13	Week 18
Enrolment:
Eligibility screen	×
Informed consent	×
Study group allocation		×
Intervention:
Task-oriented exercise				×
Generalized exercise				×
Stretching control				×
Assessments:
Baseline variables (See Table 2)		×
Primary outcome:
T25-FWT			×		×	×
Secondary outcome:
TA aMT			×		×	×
Tertiary outcomes:
Additional clinical measures			×		×	×
Additional TMS measures			×		×	×
Blood marker measures			×		×	×
Fitness measures			×		×	×
Exit surveys					×	×

Notes: T25-FWT: Timed 25-Foot Walk Test; TA aMT: tibialis anterior muscle active motor threshold; TMS: transcranial magnetic stimulation; A_x: assessment

ISSN: 2052-1847