Table 3 Changes in metabolites that were statistically significant during period 1 and period 2
Class | Period 1 | p-value1 | FDR-p | Period 2 | p-value1 | FDR-p |
|---|---|---|---|---|---|---|
Biogenic amines | Acetyl-ornithine ↓ | 0.0081 | 0.0381 | |||
Creatinine ↓ | 0.0215 | 0.0663 | Creatinine ↑ | 0.0046 | 0.0732 | |
Putrescine ↑ | 0.0398 | 0.0991 | ||||
Serotonin ↑ | 0.0005 | 0.0058 | Serotonin ↓ | 0.0005 | 0.0347 | |
Taurine ↑ | 0.0105 | 0.0436 | Taurine ↓ | 0.0024 | 0.0693 | |
Total dimethyl-arginine ↓ | 0.0105 | 0.0436 | Total dimethyl-arginine ↑ | 0.0061 | 0.0788 | |
Amino acids | Arginine ↑ | 0.0479 | 0.1836 | |||
Aspartate ↑ | 0.0025 | 0.0209 | Aspartate ↓ | 0.0005 | 0.0347 | |
Glutamine ↓ | 0.0005 | 0.0058 | Glutamine ↑ | 0.0134 | 0.1059 | |
Glutamate ↑ | 0.0118 | 0.0467 | Glutamate ↓ | 0.0105 | 0.0877 | |
Glycine ↓ | 0.0479 | 0.1152 | ||||
Histidine ↓ | 0.0398 | 0.0991 | Histidine ↑ | 0.0061 | 0.0788 | |
Ornithine ↓ | 0.0002 | 0.0058 | 0.0024 | 0.0693 | ||
Phenylalanine ↓ | 0.0061 | 0.0319 | Phenylalanine ↑ | 0.0266 | 0.1571 | |
Proline ↑ | 0.0175 | 0.1240 | ||||
Tryptophan ↓ | 0.0046 | 0.0286 | Tryptophan ↑ | 0.0024 | 0.0693 | |
Monosaccharides | Hexose ↓ | 0.0327 | 0.0893 | |||
Acylcarnitines | C0 ↑ | 0.0012 | 0.0578 | |||
C16 ↓ | 0.0012 | 0.0133 | ||||
C18:2 ↓ | 0.0215 | 0.0663 | ||||
Glycerophospholipids | lysoPC a C16:0 ↓ | 0.0017 | 0.0173 | |||
(Phophatidylcholines) | lysoPC a C16:1 ↓ | 0.0215 | 0.0663 | |||
lysoPC a C18:0 ↓ | 0.0266 | 0.0771 | ||||
lysoPC a C18:1 ↓ | 0.0034 | 0.0221 | ||||
lysoPC a C18:2 ↓ | 0.0134 | 0.0489 | ||||
lysoPC a C20:4 ↓ | 0.0002 | 0.0058 | lysoPC a C20:4 ↑ | 0.0327 | 0.1682 | |
PC aa C28:1 ↑ | 0.0046 | 0.0732 | ||||
PC aa C32:0 ↓ | 0.0079 | 0.0381 | ||||
PC aa C32:3 ↑ | 0.0266 | 0.1571 | ||||
PC aa C34:2 ↓ | 0.0024 | 0.0209 | ||||
PC aa C36:2 ↓ | 0.0266 | 0.0771 | ||||
PC aa C36:4 ↓ | 0.0005 | 0.0058 | PC aa C36:4 ↑ | 0.0191 | 0.1295 | |
PC aa C38:3 ↑ | 0.0171 | 0.1240 | ||||
PC aa C38:4 ↓ | 0.0034 | 0.0221 | PC aa C38:4 ↑ | 0.0081 | 0.0817 | |
PC aa C38:6 ↓ | 0.0097 | 0.0430 | ||||
PC aa C40:4 ↑ | 0.0360 | 0.1682 | ||||
PC aa C40:5 ↑ | 0.0426 | 0.1682 | ||||
PC ae C32:1 ↓ | 0.0134 | 0.0489 | ||||
PC ae C34:1 ↓ | 0.0392 | 0.0991 | ||||
PC ae C36:2 ↓ | 0.0327 | 0.0893 | ||||
PC ae C38:3 ↑ | 0.0330 | 0.1682 | ||||
PC ae C38:4 ↓ | 0.0005 | 0.0058 | PC ae C38:4 ↑ | 0.0398 | 0.1682 | |
PC ae C40:3 ↓ | 0.0398 | 0.0991 | PC ae C40:3 ↑ | 0.0046 | 0.0732 | |
PC ae C40:4 ↓ | 0.0134 | 0.0489 | PC ae C40:4 ↑ | 0.0398 | 0.1682 | |
PC ae C40:6 ↓ | 0.0398 | 0.0991 | ||||
PC ae C42:3 ↓ | 0.0277 | 0.0786 | ||||
PC ae C44:6 ↓ | 0.0211 | 0.0663 | ||||
Sphingolipids | SM (OH) C14:1 ↓ | 0.0026 | 0.0209 | SM (OH) C14:1 ↑ | 0.0277 | 0.1571 |
(Sphingomyelins) | SM (OH) C16:1 ↓ | 0.0061 | 0.0319 | |||
SM (OH) C22:1 ↓ | 0.0033 | 0.0221 | SM (OH) C22:1 ↑ | 0.0215 | 0.1387 | |
SM (OH) C22:2 ↓ | 0.0005 | 0.0058 | SM (OH) C22:2 ↑ | 0.0081 | 0.0817 | |
SM (OH) C24:1 ↑ | 0.0398 | 0.1682 | ||||
SM C 16:0 ↓ | 0.0002 | 0.0058 | SM C 16:0 ↑ | 0.0359 | 0.1682 | |
SM C 16:1 ↓ | 0.0002 | 0.0058 | SM C 16:1 ↑ | 0.0081 | 0.0817 | |
SM C 18:0 ↓ | 0.0026 | 0.0209 | SM C 18:0 ↑ | 0.0360 | 0.1682 | |
SM C 18:1 ↓ | 0.0005 | 0.0058 | ||||
SM C 20:2 ↓ | 0.0171 | 0.0607 | ||||
SM C 24:0 ↓ | 0.0030 | 0.0221 | SM C 24:0 ↑ | 0.0424 | 0.1682 | |
SM C 24:1 ↓ | 0.0002 | 0.0058 | ||||
Bile acids | Cholic acid ↓ | 0.0108 | 0.0436 | |||
Chenodeoxycholic acid ↓ | 0.0061 | 0.0319 | ||||
Glycocholic acid ↓ | 0.0215 | 0.0663 | ||||
Glycochenodeoxycholic acid ↓ | 0.0215 | 0.0663 | ||||
Glycodeoxycholic acid ↓ | 0.0086 | 0.0393 | ||||
Glycolithocholic acid ↓ | 0.0440 | 0.1078 | ||||
Glycoursodeoxycholic acid ↓ | 0.0005 | 0.0058 | Glycoursodeoxycholic acid ↑ | 0.0105 | 0.0877 | |
Tauromuricholic acid ↓ | 0.0051 | 0.0300 | Tauromuricholic acid ↑ | 0.0408 | 0.1682 | |
Tauroursodeoxycholic acid ↓ | 0.0063 | 0.0319 | Tauroursodeoxycholic acid ↑ | 0.0037 | 0.0732 | |
Ursodeoxycholic acid↓ | 0.0254 | 0.0766 | Ursodeoxycholic acid ↑ | 0.0105 | 0.0877 |