Outcome domain | Specific outcome variables | Specific outcome variables | ||||
---|---|---|---|---|---|---|
 | Primary outcome |  | ||||
Sport function | 1. KOOS-child ‘Sport/play’ 0-100 subscale (7 items) |  | ||||
 | Secondary outcomes | Secondary outcomes | ||||
Patient-acceptable Symptom-state | 2. PASS question (Y/N) | Â | ||||
Knee-related Quality of Life | 3. KOOS-child ‘Quality of Life’ 0-100 subscale (5 items) |  | ||||
Pain intensity and frequency (Pain flares) | 4. 4-week-average episodes of pain flares (≥4 on 0-10 NPRS) 5. Worst pain past week (0-10 NPRS) | 11. KOOS-child question P1 on ‘Pain’ subscale (1-5 Likert scale) 12. Level of pain/discomfort (EQ-D5-Y 4) | ||||
Participation in sports and physical activity | 6. 4-week average hours of sports participation | 13. 4-week average hours of MVPA 14. Satisfaction with extent of sports participation 15. Pre knee pain level of sports participation 16. Pre knee pain level of physical activity 17. Time to return to sport (week no.) | ||||
Osgood-Schlatter morphology (ultrasound imaging) | 7. Flaviis composite severity score | 18. Tendinosis signs (thickening or hyperemia) 19. Infrapatellar bursitis signs (effusion or hyperemia 20. Hyperemia of the tibial tubercle ad modum Öhberg | ||||
Pain during knee loading | 8. Anterior Knee Pain Provocation test (0-10 NPRS) | 21. Pain during knee extension test (0-10 NPRS) 22. Pressure-pain threshold at the tibial tubercle (kPa) 23. KOOS-child ‘Pain’ 0-100 subscale (8 items) 24. Known pain during manual palpation 25. Pain during countermovement jump (0-10 NPRS) | ||||
Objective knee function |  | 26. Maximal isometric knee extension strength (Nm/kg)27. Countermovement jump height (cm)28. Countermovement power (W)29. Knee extensor flexibility change (°) | ||||
Global rating of change | 9. 7-point Likert scale | 30. Satisfaction with treatment (Y/N) | ||||
Usual activities | 10. Patient-specific function scale (NRS 0-10) | 31. Problems with usual activities (EQ-D5-Y 3) | ||||
Pain beliefs | Â | 32. Kinesiophobia (Tampa Scale of Kinesiophobia, 17 items) | ||||
Health | Â | 33. Self-rated health (EQ-D5-Y 0-100 VAS) | ||||
 | Safety outcomes |  | ||||
 | 1. Any adverse events |  |