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Table 1 Clinical Results of MACI

From: MACI - a new era?

Author Patients Follow-up (months) Study design Major Findings
Basad [69] 60 24 Level I
RCT versus Microfracture
Significantly larger improvements in Lysholm, Tegner and ICRS scores were noted in the MACI group
Visna[71] 50 12 Level I
RCT versus microfracture
Significantly larger improvements in Lysholm, Tegner and IKDC scores were noted in the MACI group
Kon[70] 80 60 Level II
Prospective cohort versus microfracture
Significantly larger improvement in IKDC score was noted in the MACI group. Results deteriorated from 2 to 5 years in microfracture but not MACI group
Bartlett [45] 47 12 Level I
RCT versus ACI
Significant improvements in Cincinnati score and VAS were noted in both group - no significant differences between the two groups
Wondrasch[60] 31 24 Level 1
RCT Standard versus accelerated rehabilitation
Significant improvements in IKDC, KOOS, Lysholm and Tegner scores were noted in both group - no significant differences between the two groups
Behrens [22] 34 34 Level IV
Case series
Significant improvements in Meyer, Lysholm and ICRS scores
Ebert[64] 35 120 Level IV
Case series
Significant improvements in KOOS, SF-36 and MRI composite scores
D'Anchise[48] 35 24 Level IV
Case series
Significant improvements in VAS, IKDC, Lysholm and Tegner scores