Table 1 Clinical Results of MACI
From: MACI - a new era?
Author | Patients | Follow-up (months) | Study design | Major Findings |
|---|---|---|---|---|
Basad [69] | 60 | 24 | Level I RCT versus Microfracture | Significantly larger improvements in Lysholm, Tegner and ICRS scores were noted in the MACI group |
Visna[71] | 50 | 12 | Level I RCT versus microfracture | Significantly larger improvements in Lysholm, Tegner and IKDC scores were noted in the MACI group |
Kon[70] | 80 | 60 | Level II Prospective cohort versus microfracture | Significantly larger improvement in IKDC score was noted in the MACI group. Results deteriorated from 2 to 5 years in microfracture but not MACI group |
Bartlett [45] | 47 | 12 | Level I RCT versus ACI | Significant improvements in Cincinnati score and VAS were noted in both group - no significant differences between the two groups |
Wondrasch[60] | 31 | 24 | Level 1 RCT Standard versus accelerated rehabilitation | Significant improvements in IKDC, KOOS, Lysholm and Tegner scores were noted in both group - no significant differences between the two groups |
Behrens [22] | 34 | 34 | Level IV Case series | Significant improvements in Meyer, Lysholm and ICRS scores |
Ebert[64] | 35 | 120 | Level IV Case series | Significant improvements in KOOS, SF-36 and MRI composite scores |
D'Anchise[48] | 35 | 24 | Level IV Case series | Significant improvements in VAS, IKDC, Lysholm and Tegner scores |