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Table 2 Echocardiographic changes over 16 weeks (n=19)

From: Cardiac performance, biomarkers and gene expression studies in previously sedentary men participating in half-marathon training

 

Training group

Control group

Variable

Baseline (M±SD)

Peak (M±SD)

P value

Baseline (M±SD)

Peak (M±SD)

P value

Interventricular septum in diastole (cm)

0.925±0.102

1.003±0.128

0.028

0.925±0.115

0.982±0.138

0.074

Left ventricular internal diameter in diastole (cm)

4.803±0.490

4.818±0.490

0.864

4.726±0.409

4.876±0.451

0.067

Left ventricular posterior wall in diastole (cm)

0.961±0.092

1.075±0.123

0.003

0.930±0.134

0.963±0.133

0.439

Left ventricular mass (g)

186.6±37.4

209.2±30.0

0.009

183.0±31.1

192.1±32.2

0.114

Left ventricular mass index (g/m2)

91.4±16.8

102.8±12.8

0.008

90.4±15.1

94.2±14.1

0.194

Left ventricular end-diastolic volume (ml)

118.4±23.8

144.1±29.6

0.002

124.7±32.7

133.1±30.8

0.186

Left ventricular end-systolic volume (ml)

45.8±16.4

52.4±16.7

0.195

43.4±14.0

48.0±14.8

0.11

Ejection fraction (%)

61.9±7.9

63.8±7.8

0.461

65.2±6.5

64.2±6.5

0.47

Stroke volume (ml)

72.6±14.0

91.6±20.9

0.001

81.2±22.3

85.1±20.4

0.411

Peak early to late mitral annular velocities (E to A ratio)

1.59±0.37

1.38±0.40

0.03

1.67±0.43

1.70±0.48

0.766

  1. Table 1 shows comparison of echocardiographic changes between TRAIN and CON groups. The following significant changes occurred in the TRAIN group: (1) interventricular septal thickness increased from 0.925±0.102 cm to 1.003±0.128 cm (p=0.028), (2) posterior wall thickness in diastole increased from 0.961±0.092 cm to 1.075±0.123 cm (p=0.003), (3) LV mass increased from 186.6±37.4 g to 209.2±30.0 g (p=0.009), (4) LV mass index increased from 91.4±16.8 g/m2 to 102.8±12.8 g/m2 (p=0.008), (5) LV end diastolic volume increased from 118.4±23.8 ml to 144.1±29.6 ml (p=0.002), (5) stroke volume increased from 72.6±14.0 ml to 91.6±20. 9ml (p=0.001), and (6) the E to A ratio decreased from 1.59±0.37 to 1.38±0.40 (p=0.03). No significant changes occurred within the control group from baseline to 16 week follow-up.