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Table 2 Echocardiographic changes over 16 weeks (n=19)

From: Cardiac performance, biomarkers and gene expression studies in previously sedentary men participating in half-marathon training

  Training group Control group
Variable Baseline (M±SD) Peak (M±SD) P value Baseline (M±SD) Peak (M±SD) P value
Interventricular septum in diastole (cm) 0.925±0.102 1.003±0.128 0.028 0.925±0.115 0.982±0.138 0.074
Left ventricular internal diameter in diastole (cm) 4.803±0.490 4.818±0.490 0.864 4.726±0.409 4.876±0.451 0.067
Left ventricular posterior wall in diastole (cm) 0.961±0.092 1.075±0.123 0.003 0.930±0.134 0.963±0.133 0.439
Left ventricular mass (g) 186.6±37.4 209.2±30.0 0.009 183.0±31.1 192.1±32.2 0.114
Left ventricular mass index (g/m2) 91.4±16.8 102.8±12.8 0.008 90.4±15.1 94.2±14.1 0.194
Left ventricular end-diastolic volume (ml) 118.4±23.8 144.1±29.6 0.002 124.7±32.7 133.1±30.8 0.186
Left ventricular end-systolic volume (ml) 45.8±16.4 52.4±16.7 0.195 43.4±14.0 48.0±14.8 0.11
Ejection fraction (%) 61.9±7.9 63.8±7.8 0.461 65.2±6.5 64.2±6.5 0.47
Stroke volume (ml) 72.6±14.0 91.6±20.9 0.001 81.2±22.3 85.1±20.4 0.411
Peak early to late mitral annular velocities (E to A ratio) 1.59±0.37 1.38±0.40 0.03 1.67±0.43 1.70±0.48 0.766
  1. Table 1 shows comparison of echocardiographic changes between TRAIN and CON groups. The following significant changes occurred in the TRAIN group: (1) interventricular septal thickness increased from 0.925±0.102 cm to 1.003±0.128 cm (p=0.028), (2) posterior wall thickness in diastole increased from 0.961±0.092 cm to 1.075±0.123 cm (p=0.003), (3) LV mass increased from 186.6±37.4 g to 209.2±30.0 g (p=0.009), (4) LV mass index increased from 91.4±16.8 g/m2 to 102.8±12.8 g/m2 (p=0.008), (5) LV end diastolic volume increased from 118.4±23.8 ml to 144.1±29.6 ml (p=0.002), (5) stroke volume increased from 72.6±14.0 ml to 91.6±20. 9ml (p=0.001), and (6) the E to A ratio decreased from 1.59±0.37 to 1.38±0.40 (p=0.03). No significant changes occurred within the control group from baseline to 16 week follow-up.