Table 1 In- and exclusion criteria for participants of the Enzy-MagIC-study

• Healthy* male

• Known cardiac disease

• Age 20-65 years

• Known allergy against the active ingredient of the study medication or pineapple, papaya, or kiwi

• History of at least one successfully finished half marathon

• Intention to participate at the Munich Marathon 2013

• Known severe coagulopathy

• Subject is able to read, understand, and sign a written informed consent to participate in the Enzy-MagIC-study

• Known lactose intolerance

• Pharmaceutical treatment for diabetes mellitus or arterial hypertension

• Acute or chronic renal failure

• Acute or chronic liver disease

• Acute or chronic infection or inflammatory disease

• Use of medications or supplements influencing immune function

• Musculoskeletal or psychiatric disease

• Neoplasia

• Participation in other interventional trials