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Fig. 5 | BMC Sports Science, Medicine and Rehabilitation

Fig. 5

From: Exercise as ‘precision medicine’ for insulin resistance and its progression to type 2 diabetes: a research review

Fig. 5

Multi-factorial sequence of events that can potentially explain the progression to T2D. It is well established that genetics and/or an obesogenic lifestyle can precipitate a series of events that culminate in type 2 diabetes. While cause/consequence characteristics continue to be debated, it is undeniable that impaired insulin action is a key aspect of the pathology with ectopic fat accumulation also playing a central role

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