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Table 2 Genotypic distributions of the TNF-α -308 G>A polymorphism and their association with tendinopathy

From: Association of TNF-α -308G > A polymorphism with susceptibility to tendinopathy in athletes: a case–control study

TNF-α -308G>A Control Tendinopathy P-valuea Adjusted OR (CI 95%)
  N (%)   
All tendinopathy casesb N = 135 N = 135   
GG 108 (80.0) 97 (71.9) 0.06 1d
GA 27 (20.0) 35 (25.9) 1.45 (0.80 – 2.64)
AA 0 (0.0) 3 (2.2) -
GG+GA 135 (100.0) 132 (97.8) 0.04 1d
AA 0 (0.0) 3 (2.2) -
G 243 (90.0) 229 (84.8) 0.007 1d
A 27 (10.0) 41 (15.2) 1.63 (0.95 – 2.81)
Patellar tendinopathyc N = 135 N = 62   
GG 108 (80.0) 44 (71.0) 0.01 1d
GA 27 (20.0) 15 (24.2) -
AA 0 (0.0) 3 (4.8)  
GG+GA 135 (100.0) 59 (95.2) 0.01 1d
AA 0 (0.0) 3 (4.8) -
G 243 (90.0) 103 (83.1) 0.04 1d
A 27 (10.0) 21 (16.9) 1.92 (1.02 – 3.66)
Rotator cuff tendinopathyc N = 135 N = 50   
GG 108 (80.0) 38 (76.0) 0.34 1d
GA 27 (20.0) 11 (22.0) 1.27 (0.56 – 2.89)
AA 0 (0.0) 1 (2.0) -
GG+GA 135 (100.0) 49 (98.0) 0.17 1d
AA 0 (0.0) 1 (2.0) -
G 243 (90.0) 87 (87.0) 0.35 1d
A 27 (10.0) 13 (13.0) 1.42 (0.69 – 2.95)
Achilles tendinopathyc N = 135 N = 22   
GG 108 (80.0) 15 (68.2) 0.01 1d
GA 27 (20.0) 5 (22.7) 1.50 (0.45 – 4.93)
AA 0 (0.0) 2 (9.1) -
GG+GA 135 (100.0) 20 (90.9) 0.004 1d
AA 0 (0.0) 2 (9.1) -
G 243 (90.0) 35 (79.5) 0.03 1d
A 27 (10.0) 9 (20.5) 2.74 (1.12 – 6.75)
  1. OR Odds ratio; CI confidence interval. aP-value ≤ 0.05 was obtained through the Chi-squared Test (Pearson P-value) or Fisher’s exact test to compared control and tendinopathy cases. b OR adjusted by BMI and nutritional follow-up. c OR adjusted by Age, sex, sport modality, BMI and nutritional follow-up. d Reference value.