Table 2 Genotypic distributions of the TNF-α -308 G>A polymorphism and their association with tendinopathy
TNF-α -308G>A | Control | Tendinopathy | P-valuea | Adjusted OR (CI 95%) |
|---|---|---|---|---|
N (%) | ||||
All tendinopathy casesb | N = 135 | N = 135 | ||
GG | 108 (80.0) | 97 (71.9) | 0.06 | 1d |
GA | 27 (20.0) | 35 (25.9) | 1.45 (0.80 – 2.64) | |
AA | 0 (0.0) | 3 (2.2) | - | |
GG+GA | 135 (100.0) | 132 (97.8) | 0.04 | 1d |
AA | 0 (0.0) | 3 (2.2) | - | |
G | 243 (90.0) | 229 (84.8) | 0.007 | 1d |
A | 27 (10.0) | 41 (15.2) | 1.63 (0.95 – 2.81) | |
Patellar tendinopathyc | N = 135 | N = 62 | ||
GG | 108 (80.0) | 44 (71.0) | 0.01 | 1d |
GA | 27 (20.0) | 15 (24.2) | - | |
AA | 0 (0.0) | 3 (4.8) | ||
GG+GA | 135 (100.0) | 59 (95.2) | 0.01 | 1d |
AA | 0 (0.0) | 3 (4.8) | - | |
G | 243 (90.0) | 103 (83.1) | 0.04 | 1d |
A | 27 (10.0) | 21 (16.9) | 1.92 (1.02 – 3.66) | |
Rotator cuff tendinopathyc | N = 135 | N = 50 | ||
GG | 108 (80.0) | 38 (76.0) | 0.34 | 1d |
GA | 27 (20.0) | 11 (22.0) | 1.27 (0.56 – 2.89) | |
AA | 0 (0.0) | 1 (2.0) | - | |
GG+GA | 135 (100.0) | 49 (98.0) | 0.17 | 1d |
AA | 0 (0.0) | 1 (2.0) | - | |
G | 243 (90.0) | 87 (87.0) | 0.35 | 1d |
A | 27 (10.0) | 13 (13.0) | 1.42 (0.69 – 2.95) | |
Achilles tendinopathyc | N = 135 | N = 22 | ||
GG | 108 (80.0) | 15 (68.2) | 0.01 | 1d |
GA | 27 (20.0) | 5 (22.7) | 1.50 (0.45 – 4.93) | |
AA | 0 (0.0) | 2 (9.1) | - | |
GG+GA | 135 (100.0) | 20 (90.9) | 0.004 | 1d |
AA | 0 (0.0) | 2 (9.1) | - | |
G | 243 (90.0) | 35 (79.5) | 0.03 | 1d |
A | 27 (10.0) | 9 (20.5) | 2.74 (1.12 – 6.75) | |