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Table 3 Haplotype distributions of TNF-α in athletes and their association with tendinopathy

From: Association of TNF-α -308G > A polymorphism with susceptibility to tendinopathy in athletes: a case–control study

TNF-α Haplotypes
– 1031T>C, – 857C>T and – 308G>A
Control Tendinopathy P-valuea Adjusted OR
(CI 95%)
  N (%)   
All tendinopathy casesb N = 270 N = 270   
TCG 172 (63.7) 148 (54.8) 0.11 1d
TCA 15 (5.6) 31 (11.5) 2.65 (1.32 – 5.30)
TTG 14 (5.2) 18 (6.7) 1.74 (0.80 – 3.80)
TTA 4 (1.5) 3 (1.1) 0.79 (0.17 – 3.71)
CCG 53 (19.5) 59 (21.8) 1.35 (0.86 – 2.11)
CCA 8 (3.0) 7 (2.6) 1.03 (0.35 – 2.97)
CTG 4 (1.5) 4 (1.5) 1.50 (0.36 – 6.26)
Patellar tendinopathyc N = 270 N = 124   
TCG 172 (63.7) 71 (57.3) 0.10 1d
TCA 15 (5.6) 17 (13.7) 3.28 (1.47 – 7.31)
TTG 14 (5.2) 8 (6.5) 2.09 (0.76 – 5.71)
TTA 4 (1.5) 1 (0.8) 0.51 (0.05 – 4.81)
CCG 53 (19.5) 22 (17.7) 0.59 (0.59 – 1.98)
CCA 8 (3.0) 3 (2.4) 0.25 (0.25 – 3.92)
CTG 4 (1.5) 2 (1.6) 0.30 (0.30 – 9.81)
Rotator cuff tendinopathyc N = 270 N = 100   
TCG 172 (63.7) 55 (55.0) 0.01 1d
TCA 15 (5.6) 13 (13.0) 3.14 (1.36 – 7.24)
TTG 14 (5.2) 6 (6.0) 1.88 (0.63 – 5.00)
TTA 4 (1.5) 0 (0.0) -
CCG 53 (19.5) 25 (25.0) 1.39 (0.77 – 2.51)
CCA 8 (3.0) 0 (0.0) -
CTG 4 (1.5) 1 (1.0) 0.67 (0.07 – 6.32)
Achilles tendinopathyc N = 270 N = 44   
TCG 172 (63.7) 23 (52.3) 0.26 1d
TCA 15 (5.6) 5 (11.4) 3.79 (1.14 – 12.68)
TTG 14 (5.2) 3 (6.8) 1.99 (0.47 – 8.38)
TTA 4 (1.5) 1 (2.3) 0.93 (0.09 – 9.90)
CCG 53 (19.5) 9 (20.5) 1.33 (0.55 – 3.23)
CCA 8 (3.0) 3 (6.8) 3.83 (0.86 – 17.04)
CTG 4 (1.5) 0 (0.0) -
  1. OR Odds ratio; CI confidence interval. aP-value ≤ 0.05 was obtained through the Chi-squared Test (Pearson P-value) or Fisher’s exact test. bOR adjusted by BMI and nutritional follow-up. cOR adjusted by Age, sex, sport modality, BMI and nutritional follow-up. dReference value