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Table 4 Patient-reported outcomes with change score and standardised response mean. Values are mean (SD) unless otherwise noted

From: LOAD-intensity and time-under-tension of exercises for men who have Achilles tendinopathy (the LOADIT trial): a randomised feasibility trial

  High Load Low Load
  with High TUT with Low TUT with High TUT with Low TUT
Self-reported measures
Severity of pain using VISA-A a / 100
 Baseline 55.3 (13.4) 44.8 (18.1) 46.0 (15.8) 54.7 (9.8)
 Week-6 69.3 (14.8) 65.2 (16.7) 63.2 (16.8) 68.5 (14.0)
 Week-12 81.5 (11.2) 80.7 (17.5) 86.3 (9.0) 83.8 (13.0)
 Change score at 6-weeks, [95%CI] 14.0 [11,17] 15.0 [11,19] 17.2 [14,20] 14.0 [11,17]
 Change score at 12-weeks, [95%CI] 22.0 [19,25] 22.4 [19,25] 40.3 [37,43] 29.2 [26,32]
 SRM baseline-week 6 0.9 0.5 1.3 1.0
 SRM baseline-week 12 1.4 0.6 2.2 2.1
Worst pain using Numerical Pain Rating Scale / 10b
 Baseline 5.0 (2.2) 4.8 (3.2) 4.7 (3.0) 5.0 (3.0)
 Week-6 2 .4 (2.5) 2 .2 (1.0) 3.1 (2.2) 3.3 (2.2)
 Week-12 3 .4 (2.7) 2.3 (2.0) 2.1 (2.3) 2.3 (1.8)
 Change score at 6-weeks, [95%CI] −3.0 [−4.-2] −2.0 [−4.-1] −2.0 [− 4,1] −1.1 [− 2.1]
 Change score at 12-weeks, [95%CI] − 2.1 [− 3,1] −4.0 [−5,-2] −2.0 [− 5,-0.5] −2.5 [− 5,-1]
 SRM baseline-week 6 − 1.2 − 0.7 − 0.5 − 0.4
 SRM baseline-week 12 − 1.1 − 0.9 − 0.8 −0.9
EQ-5D-5L, Index c/ 1
 Baseline 0.71 (0.10) 0.71 (0.17) 0.72 (0.10) 0.74 (0.10)
 Week-6 0.79 (0.09) 0.76 (0.16) 0.76 (0.10) 0.78 (0.14)
 Week-12 0.84 (0.11) 0.88 (0.14) 0.84 (0.11) 0.87 (0.12)
 Change score at 6-weeks, [95%CI] 0.08 [0.1,0.3] 0.04 [−0.2,0.3] 0.02 [− 0.12,0] 0.03 [− 0.2,3]
 Change score at 12-weeks, [95%CI] 0.14 [0.1,0.5] 0.2 [− 0.1,0.3] 0.12 [− 0.1,0.3] 0.13 [0,0.3]
 SRM baseline-week 6 0.8 0.2 0.2 0.3
 SRM baseline-week 12 1.1 1.0 1.1 1.1
EQ-5D-5L, VAS d / 100
 Baseline 67.8 (15.2) 70.2 (17.8) 72.8 (16.6) 69.6 (12.0)
 Week-6 82.2 (8.5) 75.3 (9.4) 80.0 (8.3) 75.7 (13.6)
 Week-12 83.4 (13.2) 82.6 (15.5) 82.3 (10.3) 74.0 (11.5)
 Change score at 6-weeks, [95%CI] 15.0 [12,18] 6.4 [5,8] 7.0 [4,10] 6.0 [4,8]
 Change score at 12-weeks, [95%CI] 19.0 [16,22] 14.0 [12,14] 9.0 [7,11] 4.0 [2,6]
 SRM baseline-week 6 0.9 0.6 0.4 0.8
 SRM baseline-week 12 0.9 2.0 1.0 0.4
7-Day Activity Recall e
 Baseline 1041 (170) 1322 (257) 1017 (200) 1303 (296)
 Week-6 1071 (241) 1311 (237) 997 (194) 1229 (256)
 Week-12 837 (555) 1314 (211) 1046 (175) 1275 (285)
 Change score at 6-weeks, [95%CI] 29.3 [19,40] −11.0 [−23,2] −20.0 [−29,-11] 74.0 [− 62,-86]
 Change score at 12-weeks, [95%CI] 86.2 [82,96] −3.0 [− 15,5] 29.0 [− 29,-10] − 28 [−62,-86]
 SRM baseline-week 6 0.1 0 0 0
 SRM baseline-week 12 0.3 0 0.2 0
Tampa Scale for Kinesiophobia f/ 68
 Baseline 39.8 (8.7) 39.7 (3.6) 37.2 (4.9) 35.1 (12.5)
 Week-6 34.5 (8.3) 35.0 (6.1) 34.9 (4.1) 30.8 (6.8)
 Week-12 30.2 (6.4) 29.3 (6.1) 32.3 (6.4) 27.2 (4.5)
 Change score at 6-weeks, [95%CI] −5.2[−8,-2] −5.0[−7,-3] −2.3[−4,1] −4.3[−7,-2]
 Change score at 12-weeks, [95%CI] −12.1[−14,-10] −10.4[−12,-9] − 5.0[−7,-3] − 8.0[− 11,-5]
 SRM baseline-week 6 −0.6 −0.6 −0.7 −0.5
 SRM baseline-week 12 − 2.0 − 1.4 −0.6 −0.6
Pain Catastrophising Scale g/ 52
 Baseline 12.8 (6.4) 17.3 (16.5) 9.4 (7.7) 11.4 (11.3)
 Week-6 6.9 (3.2) 8.0 (7.0) 7.3 (5.9) 6.1 (5.4)
 Week-12 4.3 (4.2) 5.6 (6.2) 5.3 (5.9) 2.7 (2.1)
 Change score at 6-weeks, [95%CI] −6.0[−8,-4] −10.2[− 13,-7] −2.2[−4,-1] −5.3[− 8,-3]
 Change score at 12-weeks, [95%CI] −8.0[− 10,-7] −13.0[− 16,-10] − 4.2[− 6,-2] −9.0[− 11,-6]
 SRM baseline-week 6 −1.2 − 0.7 − 0.3 − 0.5
 SRM baseline-week 12 −1.3 − 0.7 − 0.5 − 0.8
Patient Impression of Change for pain h,i
 Week-6 (improve) 8 (67) 9 (82) 5 (42) 8 (67)
 Week-12 (improve) 7 (78) 10 (100) 10 (91) 9 (82)
Patient Impression of Change for function h,i
 Week-6 (improve) 7 (58) 8 (73) 4 (33) 9 (75)
 Week-12 (improve) 7 (78) 10 (100) 10 (91) 9 (100)
Patient-Acceptable Symptom State instrument for satisfaction i
 Week-6 (50% improve) 5 (42) 1 (10) 4 (33) 5 (42)
 Week-6 (100% improve) 7 (58) 9 (90) 8 (67) 7 (58)
 Week-12 (50% improve) 2 (22) 0 2 (18) 2 (17)
 Week-12 (100% improve) 7 (78) 10 (100) 9 (82) 10 (83)
  1. Abbreviations: aScores on the VISA–A range from 0 (worst Achilles symptoms) to 100 (no Achilles tendinopathy). b worst pain during the week scored on the NPRS range from 0 (no pain) to 10 (worst pain imaginable). cScores on the EQ-5D-5L Index Value range from < 0 (worse than dead) to 0 (dead) to 1 (full health). dScores on the EQ-5D-5L VAS range from 0 (worst imaginable health state) to 100 (best imaginable health state). eScores on the PAR are represented as daily energy expenditure (kilocalories per day). f Tampa score ranges from 17 (no fear of movement) to 68 (greater fear of movement). g Scores on CPS range from 0 (no pain) to 52 (higher levels of pain catastrophising). h dichotomised scores to “improved” and “not improved”. in (%)