| Baseline (t1) | time 1 → 2 | Post-intervention (t2) | time 2 → 3 | Post-observation (t3) | time 1 → 3 | |||
---|---|---|---|---|---|---|---|---|---|
change | p-value | change | p-value | change | p-value | ||||
Functional parameters | |||||||||
 PImax, cmH2O | 45.31 ± 23.82 | 16.38 | 0.002 | 61.69 ± 25.44 | 8.25 | 0.01 | 69.94 ± 29.83 | 24.62 | < 0.001 |
 PEmax, cmH2O | 70.94 ± 32.75 | 25.81 | 0.001 | 96.75 ± 40.93 | 5.38 | NS | 102.12 ± 36.69 | 31.19 | < 0.001 |
 Dominant hand grip strength, kg | 37.67 ± 12.32 | 5.67 | 0.017 | 43.33 ± 13.58 | −1.8 | NS | 41.53 ± 15.81 | 3.87 | NS |
 Nondominant hand grip strength, kg | 36.2 ± 14.35 | 4.47 | 0.015 | 40.67 ± 13.95 | −4.33 | 0.003 | 36.33 ± 14.21 | 0.13 | NS |
 6MWD, m | 436.81 ± 81.69 | 71.38 | 0.004 | 508.19 ± 87.97 | −14.25 | NS | 493.94 ± 114.71 | 57.12 | 0.043 |
 SaO2, % (before 6MWT) | 90.12 ± 4.72 | 2.31 | 0.029 | 92.44 ± 5.3 | −1.94 | NS | 90.5 ± 6.96 | 0.38 | NS |
 SaO2, % (after 6MWT) | 80.62 ± 12.38 | 2.44 | NS | 83.06 ± 11.24 | −1.81 | NS | 81.25 ± 10.07 | 0.62 | NS |
 Dyspnea (before 6MWT) | 0.81 ± 0.83 | −0.69 | 0.011 | 0.12 ± 0.34 | − 0.06 | NS | 0.06 ± 0.25 | − 0.75 | 0.006 |
 Dyspnea (after 6MWT) | 6 ± 2 | −1.25 | NS | 4.75 ± 1.81 | 0.06 | NS | 4.81 ± 1.94 | −1.19 | NS |
 Fatigue (before 6MWT) | 0.5 ± 0.73 | −0.38 | NS | 0.12 ± 0.34 | 0.19 | NS | 0.31 ± 0.79 | −0.19 | NS |
 Fatigue (after 6MWT) | 6.06 ± 1.95 | −0.81 | NS | 5.25 ± 2.35 | −0.5 | NS | 4.75 ± 2.24 | −1.31 | 0.01 |
Body Mass Composition | |||||||||
 Weight, kg | 75.29 ± 19.1 | 0.69 | NS | 75.98 ± 18.83 | 0.55 | NS | 76.53 ± 19.8 | 1.24 | NS |
 Body Mass Index, kg/m2 | 25.79 ± 5.78 | 0.34 | NS | 26.12 ± 5.53 | 0.18 | NS | 26.31 ± 5.96 | 0.52 | NS |
 Waist-Hip Ratio (WHR) | 0.96 ± 0.12 | 0 | NS | 0.96 ± 0.12 | 0.1 | NS | 0.95 ± 0.13 | 0.1 | NS |
 Skeletal Muscle Mass, kg | 27.54 ± 6.43 | 0.66 | NS | 28.2 ± 6.51 | 0.28 | NS | 28.48 ± 6.92 | 0.94 | NS |
 Body Fat Mass, kg | 24.54 ± 11.17 | −0.1 | NS | 24.44 ± 10.61 | 0.1 | NS | 24.54 ± 10.2 | −0.01 | NS |
 Percentage of Body Fat, % | 31.32 ± 9.08 | −0.19 | NS | 31.14 ± 8.8 | 0.01 | NS | 31.14 ± 7.85 | −0.18 | NS |
 Arm Circumference | 32.28 ± 5.47 | 0.22 | NS | 32.5 ± 5.37 | −0.06 | NS | 32.34 ± 5.36 | 0.16 | NS |
 Arm Muscle Circumference | 25.29 ± 4.11 | 0.43 | 0.005 | 25.73 ± 4.04 | −0.21 | NS | 25.51 ± 3.99 | 0.22 | NS |
SF-36 | |||||||||
 Physical Functioning | 55 ± 28.81 | 12.81 | < 0.001 | 67.81 ± 24.76 | −3.75 | NS | 64.06 ± 24.17 | 9.07 | NS |
 Role Physical | 50 ± 29.4 | 17.97 | 0.015 | 67.97 ± 25.81 | −8.59 | NS | 59.38 ± 26.02 | 9.38 | NS |
 Bodily Pain | 63.38 ± 29.6 | 6.56 | NS | 69.94 ± 28.74 | 3.62 | NS | 73.56 ± 24.39 | 10.19 | NS |
 General Health | 41.06 ± 24.06 | 4.19 | NS | 45.25 ± 18.83 | −1.94 | NS | 43.31 ± 17.37 | 2.25 | NS |
 Vitality | 50.39 ± 24.52 | 10.55 | 0.022 | 60.94 ± 18.61 | −2.34 | NS | 58.59 ± 21.27 | 8.2 | NS |
 Social Functioning | 66.41 ± 28.77 | 4.69 | NS | 71.09 ± 22.69 | 0.78 | NS | 71.88 ± 27.2 | 5.47 | NS |
 Role Emotional | 69.27 ± 32.16 | 13.02 | 0.029 | 82.29 ± 20.61 | −4.17 | NS | 78.13 ± 27.87 | 8.86 | NS |
 Mental Health | 68.75 ± 22.55 | 0.94 | NS | 69.69 ± 19.1 | −1.56 | NS | 68.12 ± 18.25 | −0.62 | NS |
 Physical Component Summary | 40.11 ± 11.35 | 4.66 | 0.005 | 44.77 ± 9.05 | −0.98 | NS | 43.79 ± 8.13 | 3.68 | NS |
 Mental Component Summary | 47.55 ± 13.33 | 2.07 | NS | 49.63 ± 9.27 | −0.75 | NS | 48.88 ± 11.27 | 1.33 | NS |
Fatigue Severity Scale | 4.08 ± 1.6 | −0.7 | NS | 3.38 ± 1.5 | 0.24 | NS | 3.61 ± 1.5 | −0.47 | NS |