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Table 1 Characteristics of the included studies

From: Effectiveness and safety of aerobic exercise for rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials

Author, year

Country

Function status

Sample (I/C)

Age (I/C)

Disease duration (I/C)

Intervention

Frequency (per week)

Duration (min)

Intensity

Length (week)

Comparison

Outcomes

Van den Ende, 2000

Netherlands

nr

34/30

62 ± 13/58 ± 14

8 ± 8/7 ± 8

Muscle strengthening exercises, bicycle training

3

15

60% of max HR

4

Usual care

①②④⑥⑦

De Jong, 2003

Netherlands

ACR I–III

150/150

54.0 ± 16/53.3 ± 18

7.5 ± 10.8/5 ± 7

Bicycle training, exercise circuit, sport or game

2

75

70–90% of max HR

96

Usual care

â‘ â‘¡

Melikoglu,2006

Turkey

ACR I–II

20/20

46.42 ± 8.34/50.29 ± 9.70

6.72 ± 6.31/6 ± 5.67

Dynamic exercise performed on treadmill

2

20

60% of max HR

2

Range of motion (ROM) exercise

①⑤⑥⑦⑪

Neuberger, 2007

US

nr

84/75

55.5 ± 7.5

8 ± 12.38

Low-impact aerobics, strengthening

3

60

60–80% of max HR

12

Usual care

③⑤⑥⑧⑨

Baillet, 2009

France

ACR I–II

25/23

51.6 ± 8.3/56.3 ± 12.8

10.5 ± 8.0/11.7 ± 6.2

Cycling, running or resisting pulley cord,

5

45

60–80% of max HR

48

Education

â‘ â‘¡

Flint-Wagner, 2009

US

ACR I–II

16/8

52.2 ± 13/49.0 ± 12.6

15.4 ± 10.8/11.2 ± 8.9

Strength training, aerobic exercise, abdominal exercises

3

75

nr

16

Usual care

①⑦

Breedland, 2011

Netherlands

Steinbrocker I–II

19/15

45 ± 11.9/51.8 ± 9.4

9.7 ± 14.0/5.9 ± 7.2

Muscle exercise circuit and bicycle training, sports, aqua jogging

2

90

More than 60% of max HR

8

Usual care

②⑨

Stavropoulos-Kalinoqlou, 2013

UK

nr

20/20

55.0 ± 9.8/52.8 ± 10.1

5.5 ± 1.68/7.0 ± 1.25

Treadmills, and cycle, hand and rowing erg-ometers

3

50–60

70% VO2 max

24

Education

①②⑤

Alghadir, 2016

Saudi Arabia

nr

20/20

45.9 ± 6.3/55.6 ± 12.41

12.3 ± 2.01/12.9 ± 3.01

Supervised aerobic exercise using treadmills

3

45–60

Moderate intensity, 30–45% of VO2max

24

Usual care

①②③④⑤⑥

Lange, 2019

Sweden

DAS28 < 5.1

36/38

69.14 ± 2.61/70.11 ± 2.30

15.4 ± 10.7/17.4 ± 10.9

Aerobic exercise and resistance exercis

3

30

70–89%of max HR

20

Home-based non-aerobic exercise

①⑨⑩

Andersson, 2020

Sweden

DAS28 < 5.1

24/25

69 ± 2.7/70 ± 2.4

13 ± 2.43/20 ± 3.25

Gym-based resistance and aerobic exercise

3

30

70–90%of max HR

20

Home-based non-aerobic exercise

①⑨⑩

Azeez, 2020

Ireland

nr

28/24

58.5 ± 9.75/63 ± 9.5

2 ± 4.75/9 ± 11.5

Cardiovascular exercise like walking, cycling or swimming and strength training

nr

nr

nr

12

Usual care

①②⑤⑥⑨

García-Morales, 2020

Mexico

ACR I–III

37/31

49.7 ± 11.4/49.1 ± 12.1

14 ± 3.88/8 ± 5

Articular rotation, bicycle, anaerobic exercise, recreational games,

2

80–90

65–85% of max HR

12

Education

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  1. ① HAQ-DI Health Assessment Questionnaire-Disability Index, ② DAS-28 Disease Activity Score 28, ③ TJC Tender joint count, ④ SJC Swollen joint count, ⑤ CPR C-reactive protein, ⑥ ESR erythrocyte sedimentation rate, ⑦ VAS visual analogue scale, ⑧ McGill Pain Questionnaire, ⑨VO2max maximal oxygen consumption, ⑩ STS test Sit to Stand test, ⑪ RAI Ritchie articular index, nr not reported/inapplicable, HR heart rate, ACR American College of Rheumatology, DEP dynamic exercise program