Table 3 Change in outcomes by questionnaires after 6 months maintenance treatment phase

38.3 ± 4.8

37.7 ± 6.0

40.2 ± 4.1

40.2 ± 6.2

40.3 ± 5.0

39.1 ± 5.7*

0.115

0.387

0.01

32.0 ± 24.0

25.6 ± 16.8

34.3 ± 23.8

23.7 ± 19.7*

33.5 ± 23.6

25.5 ± 19.3*

< 0.001

0.675

0.01

16.0 ± 16.7

11.5 ± 11.7

18.3 ± 27.0

20.1 ± 36.1

18.0 ± 17.1

11.4 ± 9.8*

0.105

0.178

0.03

48.0 ± 33.6

37.1 ± 23.0*

52.6 ± 35.7

43.8 ± 40.7*

51.5 ± 29.7

36.9 ± 22.8*

< 0.001

0.685

0.01

3.67 ± 2.40

4.30 ± 3.20

4.31 ± 3.14

4.19 ± 3.64

3.70 ± 3.35

3.88 ± 4.29

0.319

0.419

0.01

2.77 ± 2.52

3.33 ± 3.08

3.33 ± 3.10

2.98 ± 3.02

2.33 ± 2.51

2.98 ± 3.27*

0.140

0.064

0.04

49.6 ± 7.9

50.0 ± 8.6

50.8 ± 7.6

51.4 ± 9.7

51.7 ± 6.2

51.9 ± 5.6

0.467

0.957

0.00

54.0 ± 5.5

54.0 ± 5.5

52.2 ± 9.1

52.2 ± 9.1

53.9 ± 6.9

53.8 ± 6.9

0.382

0.394

0.01