Fig. 2

Study schema of research activities and neoadjuvant chemotherapy. All baseline testing (cardiopulmonary exercise test (CPET) and surveys) was conducted prior to starting chemotherapy and the exercise intervention was initiated concomitant to chemotherapy. Follow up testing was completed prior to surgical resection. Chemotherapy treatment lasted 16–24 weeks depending on treatment and individual delays. The introductory phase of the intervention lasted 4 weeks, followed by 7 weeks of an intermediate ramp phase. At week 12 the maintenance phase began and continued until chemotherapy and follow-up testing was completed