Association between matrix metalloproteinase-3 gene polymorphisms and tendon-ligament injuries: evidence from a meta-analysis

Guo, Rui; Aizezi, Aihaiti; Fan, Yong; Ji, Zhe; Li, Wenzong; Li, Yongxian; Wang, Zhigang; Ning, Kai

doi:10.1186/s13102-022-00421-5

BMC Sports Science, Medicine and Rehabilitation

Table 1 Main characteristics of included studies

From: Association between matrix metalloproteinase-3 gene polymorphisms and tendon-ligament injuries: evidence from a meta-analysis

Author	Year	Country/region	Ethnicity	Design	Diagnosis	Case			Control			HWE
Author	Year	Country/region	Ethnicity	Design	Diagnosis	VV	VW	WW	VV	VW	WW	HWE
Rs679620						AA	AG	GG	AA	AG	GG
Briški N	2020	Croatia	Caucasian	Case–control	ATEN	16	30	17	9	51	32	0.08
El Khoury L (I)	2016	UK	Caucasian	Case–control	ATEN	31	46	16	35	71	25	0.31
El Khoury L (II)	2016	UK	Caucasian	Case–control	ARUP	6	8	11	35	71	25	0.31
Figueiredo EA	2020	Brazil	Mixed	Case–control	RCT	41	111	58	90	275	200	0.78
Gibbon A (I)	2017	Australia	Caucasian	Case–control	ATEN	20	40	17	39	94	58	0.94
Haug KBF	2018	Norway	Caucasian	Cohort	PTEN	5	21	7	22	53	18	0.18
Lulinska-Kuklik E	2019	Poland	Caucasian	Case–control	ACLI	54	107	68	59	93	40	0.77
Nie G	2019	China	Asian	Case–control	ATEN	78	460	546	234	950	1004	0.68
Posthumus M	2012	South Africa	Caucasian	Case–control	ACLI	53	94	34	57	99	59	0.25
Raleigh SM (I)	2009	South Africa	Caucasian	Case–control	ATEN	15	32	28	24	55	19	0.22
Raleigh SM (II)	2009	South Africa	Caucasian	Case–control	ARUP	8	20	10	24	55	19	0.22
Rs591058						TT	TC	CC	TT	TC	CC
Briški N	2020	Croatia	Caucasian	Case–control	ATEN	10	25	13	9	51	32	0.08
Gibbon A (I)	2017	Australia	Caucasian	Case–control	ATEN	20	39	18	38	93	60	0.86
Gibbon A (III)	2017	South Africa	Caucasian	Case–control	ACLI	80	182	64	59	106	60	0.39
Haug KBF	2018	Norway	Caucasian	Cohort	PTEN	5	21	7	22	51	20	0.35
Lulinska-Kuklik E	2019	Poland	Caucasian	Case–control	ACLI	54	107	68	59	93	40	0.77
Raleigh SM (I)	2009	South Africa	Caucasian	Case–control	ATEN	15	32	26	25	53	19	0.34
Raleigh SM (II)	2009	South Africa	Caucasian	Case–control	ARUP	9	20	10	25	53	19	0.34
Rs650108						GG	GA	AA	GG	GA	AA
Briški N	2020	Croatia	Caucasian	Case–control	ATEN	35	23	5	31	50	11	0.18
Gibbon A (I)	2017	Australia	Caucasian	Case–control	ATEN	34	27	6	90	56	13	0.32
Gibbon A (III)	2017	South Africa	Caucasian	Case–control	ACLI	205	99	15	122	90	12	0.38
Haug KBF	2018	Norway	Caucasian	Cohort	PTEN	19	13	1	54	35	4	0.58
Raleigh SM (I)	2009	South Africa	Caucasian	Case–control	ATEN	39	28	7	51	42	2	0.05
Raleigh SM (II)	2009	South Africa	Caucasian	Case–control	ARUP	20	16	2	51	42	2	0.05
Rs3025058						5A5A	5A6A	6A6A	5A5A	5A6A	6A6A
Assunção JH	2017	Brazil	Mixed	Case–control	RCT	15	38	11	4	44	16	0.01
Gibbon A (I)	2017	Australia	Caucasian	Case–control	ATEN	20	40	17	40	93	57	0.86
Gibbon A (II)	2017	South Africa	Caucasian	Case–control	ATEN	12	30	27	24	51	18	0.33
Gibbon A (III)	2017	South Africa	Caucasian	Case–control	ACLI	77	185	64	57	108	60	0.55
Godoy-Santos AL	2017	Brazil	Mixed	Case–control	TTEN	15	34	19	12	61	27	0.02
Malila S	2011	Thailand	Asian	Case–control	ACLI	1	22	63	1	20	79	0.84
Miao K	2019	China	Asian	Case–control	RCT	6	48	96	8	42	100	0.21

V variant allele, W wild allele, HWE Hardy–Weinberg Equilibrium, ATEN achilles tendinopathy, ARUP achilles tendon rupture, ACLI anterior cruciate ligament injury, PTEN patellar tendinopathy, RCT rotator cuff tear, TTEN tibial tendinopathy

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ISSN: 2052-1847

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