Association between matrix metalloproteinase-3 gene polymorphisms and tendon-ligament injuries: evidence from a meta-analysis

Guo, Rui; Aizezi, Aihaiti; Fan, Yong; Ji, Zhe; Li, Wenzong; Li, Yongxian; Wang, Zhigang; Ning, Kai

doi:10.1186/s13102-022-00421-5

BMC Sports Science, Medicine and Rehabilitation

Table 3 Associations of matrix metalloproteinase 3 gene polymorphisms and tendon-ligament injuries

From: Association between matrix metalloproteinase-3 gene polymorphisms and tendon-ligament injuries: evidence from a meta-analysis

Genetic model	Test of association			No. of cohorts	Test of association		Statistical model
Genetic model	OR	95%CI	P	No. of cohorts	I² (%)	P	Statistical model
Rs679620
A versus G
Overall	0.97	0.81–1.17	0.780	11	72	< 0.001	R
Caucasian	0.96	0.76–1.21	0.740	9	66	0.003	R
ATEN	1.04	0.77–1.39	0.810	5	76	0.002	R
ARUP	0.70	0.47–1.04	0.080	2	0	0.400	F
ACLI	0.95	0.56–1.64	0.860	2	87	0.006	R
AA versus GG
Overall	0.95	0.64–1.40	0.790	11	73	< 0.001	R
Caucasian	0.94	0.58–1.52	0.810	9	66	0.002	R
ATEN	1.10	0.56–2.14	0.790	5	79	< 0.001	R
ARUP	0.50	0.23–1.09	0.080	2	0	0.550	F
ACLI	0.93	0.32–2.72	0.890	2	87	0.006	R
AG versus GG
Overall	0.92	0.71–1.20	0.540	11	61	0.004	R
Caucasian	0.84	0.57–1.23	0.370	9	61	0.009	R
ATEN	0.89	0.78–1.03	0.120	5	46	0.120	F
ARUP	0.45	0.23–0.87	0.020	2	50	0.160	F
ACLI	1.05	0.44–2.52	0.910	2	84	0.010	R
AA + AG versus GG
Overall	0.92	0.70–1.22	0.580	11	70	< 0.001	R
Caucasian	0.86	0.58–1.28	0.460	9	68	0.002	R
ATEN	0.95	0.65–1.40	0.800	5	63	0.030	R
ARUP	0.46	0.25–0.87	0.020	2	37	0.210	F
ACLI	1.01	0.39–2.59	0.990	2	88	0.004	R
AA versus AG + GG
Overall	1.00	0.77–1.30	1.000	11	57	0.009	R
Caucasian	1.03	0.83–1.26	0.810	9	40	0.100	F
ATEN	0.85	0.70–1.05	0.130	5	77	0.002	R
ARUP	0.84	0.43–1.65	0.610	2	0	0.940	F
ACLI	0.89	0.55–1.46	0.650	2	60	0.110	R
Rs591058
T versus C
Overall	0.96	0.76–1.20	0.700	7	59	0.020	R
ATEN	1.08	0.66–1.77	0.760	3	75	0.020	R
ACLI	0.90	0.59–1.37	0.630	2	81	0.020	R
TT versus CC
Overall	0.93	0.58–1.51	0.780	7	61	0.020	R
ATEN	1.25	0.43–3.59	0.680	3	76	0.020	R
ACLI	0.83	0.36–1.93	0.670	2	81	0.020	R
TC versus CC
Overall	0.97	0.66–1.42	0.860	7	57	0.030	R
ATEN	0.91	0.44–1.8	0.800	3	66	0.050	R
ACLI	1.05	0.45–2.46	0.910	2	86	0.008	R
TT + TC versus CC
Overall	0.95	0.66–1.41	0.800	7	64	0.010	R
ATEN	0.98	0.45–2.17	0.970	3	75	0.020	R
ACLI	0.97	0.41–2.27	0.940	2	88	0.005	R
TT versus TC + CC
Overall	0.90	0.72–1.13	0.370	7	28	0.220	F
ATEN	1.24	0.82–1.90	0.310	3	48	0.150	F
ACLI	0.81	0.61–1.08	0.150	2	0	0.360	F
Rs650108
G versus A
Overall	1.15	0.96–1.37	0.140	6	44	0.110	F
ATEN	1.06	0.81–1.39	0.670	3	70	0.040	R
GG versus AA
Overall	1.03	0.64–1.67	0.900	6	31	0.200	F
ATEN	0.85	0.24–2.92	0.790	3	66	0.050	R
GA versus AA
Overall	0.77	0.47–1.26	0.300	6	0	0.520	F
TEN	0.71	0.36–1.39	0.320	3	40	0.190	F
GG + GA versus AA
Overall	0.91	0.57–1.46	0.700	6	8	0.360	F
ATEN	0.77	0.28–2.13	0.610	3	53	0.120	R
GG versus GA + AA
Overall	1.26	1.00–1.57	0.050	6	45	0.100	F
ATEN	1.21	0.62–2.36	0.570	3	72	0.030	R
Rs3025058
5A versus 6A
Overall	1.20	1.03–1.40	0.020	6	0	0.740	F
Caucasian	1.16	0.95–1.42	0.510	2	0	0.510	F
Brazilians	1.38	1.00–1.92	0.050	2	0	0.340	F
Asian	1.12	0.80–1.56	0.520	2	0	0.540	F
ACLI	1.14	0.91–1.42	0.260	2	0	0.630	F
RCT	1.25	0.92–1.71	0.150	2	50	0.160	F
5A5A versus 6A6A
Overall	1.48	1.06–2.08	0.020	6	0	0.350	F
Caucasian	1.37	0.91–2.08	0.130	2	0	0.540	F
Brazilians	2.64	1.23–5.67	0.010	2	0	0.180	F
Asian	0.83	0.30–2.30	0.720	2	0	0.760	F
ACLI	1.27	0.78–2.05	0.340	2	0	0.990	F
RCT	1.98	0.30–13.30	0.480	2	79	0.030	R
5A6A versus 6A6A
Overall	1.31	1.03–1.67	0.030	6	0	0.700	F
Caucasian	1.55	1.09–2.42	0.020	2	0	0.790	F
Brazilians	1.95	0.55–1.67	0.870	2	0	0.430	F
Asian	1.25	0.84–1.88	0.280	2	0	0.730	F
ACLI	1.54	1.07–2.21	0.020	2	0	0.710	F
RCT	1.21	0.78–1.86	0.400	2	0	0.920	F
5A5A + 5A6A versus 6A6A
Overall	1.32	1.05–1.67	0.020	6	0	0.850	F
Caucasian	1.50	1.07–2.10	0.020	2	0	0.970	F
Brazilians	1.17	0.68–2.00	0.570	2	0	0.350	F
Asian	1.20	0.81–1.77	0.360	2	0	0.640	F
ACLI	1.46	1.03–2.06	0.030	2	0	0.840	F
RCT	1.22	0.81–1.85	0.340	2	0	0.480	F
5A5A versus 5A6A + 6A6A
Overall	1.36	0.85–2.19	0.200	6	47	0.090	R
Caucasian	1.01	0.72–1.41	0.940	2	0	0.330	F
Brazilians	2.80	1.44–5.45	0.002	2	16	0.280	F
Asian	0.78	0.29–2.15	0.640	2	0	0.770	F
ACLI	0.92	0.62–1.35	0.660	2	0	0.860	F
RCT	1.82	0.30–10.93	0.510	2	80	0.020	R

OR odds ratio, CI confidence interval, F fixed-effects model, R random-effects model, ATEN Achilles tendinopathy, ARUP achilles tendon rupture, ACLI anterior cruciate ligament injury, PTEN patellar tendinopathy, RCT rotator cuff tear, TTEN tibial tendinopathy

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ISSN: 2052-1847

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