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Table 1 The Oxford 2011 Levels of Evidence

From: Physical activity induced alterations of gut microbiota in humans: a systematic review

Evidence level (treatment benefits)

Level 1: Systematic review of randomized trials or n-of-1 trials

Level 2: Randomized trial or observational study with dramatic effect

Level 3: Non-randomized controlled cohort/follow-up study

Level 4: Case-series, case control study, or historically controlled study

Level 5: Mechanism-based reasoning