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Table 1 Clusters of significant volume changes in contrast t3-t1, describing GM volume decrease from start to time point 3 at a mean of 4001 km

From: Regionally accentuated reversible brain grey matter reduction in ultra marathon runners detected by voxel-based morphometry

Functional region Anatomical localisation Side Brodmann area x y z z-score
Bilateral temporal cortex and parietal lobe Medial temporal gyrus Right 21 51 -43 7 6.60
37 45 -62 2 6.35
22 54 -39 1 6.35
Superior temporal gyrus and postcentral gyrus, parietal lobe Right 42, 40 56 -30 19 5.73
Medial temporal gyrus Left 21 -56 -29 -7 5.59
21 -53 -37 -5 5.39
21 -48 -42 0 5.39
Uncus Left 20 -34 -19 -28 5.69
Bilateral occipitoparietal cortex Angular gyrus Right 39 46 -51 33 6.07
Precuneus Right 19 32 -68 34 5.47
Precuneus Right 7 14 -68 41 5.51
7 8 -72 45 5.51
19 15 -81 38 5.42
Precuneus   19 -40 -71 38 5.96
Angular gyrus Left 39 -48 -62 34 5.29
Precuneus   7 -24 -73 43 5.08
Precuneus Left 7 -15 -75 48 5.20
Lingual gyrus Left 18 -15 -85 -9 5.12
Bilateral ACC/perigenual cingulate cortex adjacent medial prefrontal cortex Cingulate gyrus Left 24 -3 4 26 6.15
Left 24 -7 1 34 5.96
Right 24 1 -3 31 5.68
Cingulate gyrus Right 31 1 -27 35 5.16
Superior frontal gyrus Left 8 -3 39 46 5.43
Superior frontal gyrus Right 9 27 51 29 5.81
Medial frontal gyrus Left 10, 11 -3 44 -11 5.13
Right caudate head Caudate   Caudate head 13 12 0 5.50
Caudate Right Caudate head 6 7 3 5.42
Anterior cingulate   24 5 27 -4 5.36
  1. Masking as described in the method section, p < 0.05 FWE corrected. In the columns x, y and z brain coordinates in stereotactic MNI-space are listed. Z-score refers to the standard norm distribution’s z-statistic.