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Table 3 Adequate cut-off points (AUC ≥ 0.70 simultaneously in both sexes and r ≤ 0.30 with body size) of handgrip strength (HGS), one maximum repetition measurement for knee extensors (1RM) and isokinetic knee extension peak torque at 60°/s (PT) to identify muscle weakness

From: Identification of muscle weakness in older adults from normalized upper and lower limbs strength: a cross-sectional study

Variable Unit Men (n = 29) Women (n = 65)
AUC Cut-off point (≤) Sens (%) Spe (%) AUC Cut-off point (≤) Sens (%) Spe (%)
HGS (kg)          
/Forearm circumference (cm) 0.74* 1.33 86 59 0.70* 1.04 84 58
1RM (kg)          
/Body mass (kg) 0.77* 0.85 86 68 0.76 0.54 68 78
/Forearm circumference (cm) 0.75* 2.16 86 77 0.70* 1.38 60 75
/Calf circumference   0.74* 1.65 86 77 0.70* 1.06 72 68
/Chest circumference   0.76* 0.64 86 73 0.71* 0.4 72 65
/Waist circumference   0.78* 0.73 100 59 0.72* 0.37 60 80
/Triceps skinfold (mm) 0.81 4.22 86 68 0.70* 1.40 60 75
/Bitrochanteric breadth   0.73* 1.72 86 77 0.70* 1.16 76 60
/Bimalleolar breadth   0.73* 8.77 86 77 0.70* 5.77 76 65
/Elbow breadth   0.73* 9.36 86 73 0.70* 6.57 76 63
/SA (m2) 0.75* 31.6 86 77 0.72* 21.2 72 68
/MAMC (cm) 0.77* 2.42 86 73 0.72* 1.54 64 75
/CAMA (cm2) 0.71* 2.03 100 41 0.73* 0.90 52 93
/FFM(Lean et al. [44]) (kg) 0.76* 1.11 86 77 0.72* 1.00 72 68
/FFM(Baumgartner et al. [46]) (kg) 0.78* 1.13 83 73 0.75 0.83 76 64
/Body mass0.44 (kg) 0.75* 9.04 86 77 0.71* 6.03 76 63
/Body mass0,67 (Jaric [56])   0.78* 3.40 86 77 0.73 2.28 76 65
/Body mass0.96 (Abdalla et al. [53])   0.77* 1.00 86 68 0.75 0.45 44 100
/Body mass0.69 (Abdalla et al. [53])   0.78* 3.06 86 77 0.73* 1.48 44 98
/Calf circumference1.10 (cm) 0.75* 1.14 86 77 0.71* 0.70 68 73
/Bimalleolar breadth1.20 (mm) 0.71* 6.01 86 68 0.70* 3.93 76 65
/(Body mass*height)0.48 (kg*m) 0.75* 5.83 86 77 0.72* 4.06 76 65
/SA0.93 (m2) 0.75* 33 86 77 0.72* 22.7 76 65
/FFM0.88(Lean et al. [44]) (kg) 0.75* 1.77 86 77 0.71* 1.53 76 65
/FFM0.67(Baumgartner et al. [46])   0.76* 3.94 83 77 0.72* 2.91 76 64
PT (Nm)          
/Height (m) 0.93 54.1 86 95 0.74 44.1 64 75
/Knee height (cm) 0.94 1.83 100 86 0.75 1.44 68 73
/SA (m2) 0.94 56.9 100 82 0.81 36.3 64 88
/FFM(Lean et al. [44]) (kg) 0.93 1.79 86 95 0.81 1.84 76 80
/Left leg LST (g) 0.82 0.015 100 55 0.76 0.012 68 80
/Right leg LST   0.77* 0.015 100 50 0.78 0.013 76 78
/Legs LST   0.81* 0.0063 71 82 0.77 0.0065 76 78
/ASM (kg) 0.81* 4.66 71 86 0.77 5.01 76 78
/FFM(Baumgartner et al. [46])   0.93 1.63 83 95 0.85 1.60 88 77
/FFM(DXA)   0.84 2.08 100 59 0.79 1.89 76 75
/Body mass0.67 (Davies and Dalsky [28]) (kg) 0.93 5.06 86 95 0.82 3.71 68 88
/Body mass0.72 (Davies and Dalsky [28])   0.94 4.1 86 95 0.82 3.14 72 85
/Body mass0.74 (Davies and Dalsky [28])   0.93 3.77 86 95 0.82 2.87 72 85
/Body mass0.67 (Jaric [56])   0.93 5.06 86 95 0.82 3.71 68 88
/Height3.27 (m) 0.86 19.2 100 77 0.74 17.4 72 65
/Knee height1.82 (cm) 0.90 0.068 100 86 0.74 0.053 64 75
/Half arm span1.62   0.88 0.076 100 73 0.75 0.066 84 58
/Biacromial breadth2.15 (mm) 0.82 0.038 86 68 0.77 0.03 76 73
/Bimalleolar breadth1.54   0.81* 5.04 86 73 0.80 4.64 92 60
/(Body mass*height)0.43 (kg*m) 0.94 13 100 82 0.80 10.5 84 65
/SA0.83 (m2) 0.94 53.8 86 95 0.80 50 84 65
/Left leg LST0.43 (g) 0.92 2.26 100 77 0.77 1.83 76 70
/Right leg LST0.48   0.90 1.39 100 73 0.78 1.16 80 70
/Legs LST0.47   0.92 1.07 100 73 0.77 0.87 76 70
  1. Dependent variable (primary outcome): functional limitation (6MWT < 400 m)
  2. AUC area under the curve, p significance, Sens sensibility, Spe specificity, SA human body surface area, MAMC mid-arm muscle circumference, CAMA corrected arm muscle area, FFM Fat-free mass, LST lean soft tissue, ASM appendicular skeletal muscle mass, DXA Dual-energy X-ray absorptiometry, 6MWT six-minute walk test
  3. *p < 0.05 and p < 0.001 (statistically significant AUC)