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Table 3 Pentagram of Concussion Hypothesized Anatomical Mechanisms

From: The pentagram of concussion: an observational analysis that describes five overt indicators of head trauma

Response

Nuclei

Tract

Effector

Fencing response

     First order

Lateral vestibular nucleus

Vestibulospinal fasciculus

Ipsilateral limb extensor (excitatory),

     Second order

N/A

N/A

Ipsilateral limb flexors (inhibitory)

Seizing

     First order

Oral pontine reticular nucleus

Reticulospinal

Proximal muscles, axial muscles

     Second order

N/A

N/A

 

Seizing

     First order

Pontine tegmentum

Reticulospinal

Proximal muscles, axial muscles

     Second order

N/A

N/A

 

Snoring

     First order

Nucleus ambiguous

Cranial nerve IX, X

Oropharyngeal musculature

     Second order

N/A

N/A

 

Vomiting

     First order

Area postrema

Unnamed efferent tracts

Cardiac sphincter, intercostal

     Second order

Vomiting center; nucleus tractus solitarii

Dorsal motor nucleus of X, ventral respiratory nucleus

Motor neurons, abdominal motor neurons

Vomiting

     First order

Dorsal motor nucleus of cranial nerve X

Cranial nerve X

Cardiac sphincter

     Second order

N/A

N/A

 

Vomiting

     First order

Ventral respiratory nucleus

Reticulospinal, phrenic nerve

Intercostal motor neurons, abdominal 

     Second order

N/A

N/A

Motor neurons

Crying

     First order

Superior salivatory nucleus

Greater petrosal nerve

Lacrimal gland

     Second order

Pterygopalatine ganglion

V1

 
  1. Each pennant of the Pentagram of Concussion may be attributed to transient neurological dysfunction of a brainstem nuclei following head injury. This table represents the proposed mechanisms of each response. Each nucleus has neuroanatomical vulnerability due to the anatomical location and known diffuse BBB disruption in the brainstem. Activation of downstream neuronal circuitry (first and second order nuclei) can activate an effector producing the observed response