Fig. 3
Network based on the Spearman correlation between changes in biomarkers during period 1 (between “Time point 1” and “Time point 2”); threshold: Spearman correlation coefficient p < 0.05 (42 nodes, 87 edges). Blue edges represents negative correlation, red edges represents positive correlation. Abbreviations: SBP = systolic blood pressure; DBP = diastolic blood pressure; HbA1c = hemoglobin A1c; LDL = low-density lipoprotein-cholesterol; Ac-Orn = acetyl-ornithine; Total DMA = total dimethyl-arginine; Asp = aspartate; Gln = glutamine; Glu = glutamate; Phe = phenylalanine; Trp = tryptophan; lysoPC = lyso-phosphatidylcholine; PC aa = diacyl phosphatidylcholine; PC ae = acyl-alkyl phosphatidylcholine; SM = sphingomyelin; CA = cholic acid; CDCA = chenodeoxycholic acid; GDCA = glycodeoxycholic acid; GUDCA = glycoursodeoxycholic acid; TUDCA = tauroursodeoxycholic acid; TMCA_ab = tauromuricholic acid (sum of alpha and beta)