Table 2 Study schedule

Timepoint

Mo 0

Weekly

Mo 1

Mo 2

Mo 3

Mo 5

Mo 8

Mo 10, 12, 24, 48

Enrollment procedures

 Clinical visit

X

X

X

X

X

 At home

X

X

X

X

 Phone screening

X

 Written information

X

X

 Verbal information

X

X

 Written consent

X

 Allocation

X

Clinical assessments

 Clinical examination

X

X

 Peak Height Velocity

X

X

X

X

 Adverse events

X

X

X

X

X

X

 Previous & concomitant treatments

X

X

X

X

X

X

Clinical tests

 Pressure-Pain threshold

X

X

X

X

X

 Knee extension strength

X

X

X

X

X

 Countermovement jump

X

X

X

X

X

 Modified Thomas test

X

X

X

X

X

 Anterior knee pain provocation test

X

X

X

X

X

Objective longitudinal measures

 Physical activity (sensors)

Imaging

 Ultrasound scanning

X

X

X

X

Patient-reported questionnaires

 KOOS-child 4 subscales

X

X

X

X

X

X

X

 Patient Acceptable Symptom State

X

X

X

X

X

X

X

 Global rating of change

X

X

X

X

X

X

 Sport & Physical activity

X

X

X

X

X

X

X

X

 Pain history

X

X

X

X

X

X

X

X

 EuroQol 5-Dimension Youth

X

X

X

X

X

 Tampa Scale of Kinesiophobia

X

X

X

 Working Alliance Inventory

X

 Miscellaneous health^b

X

 Pubertal stage (Tanner)

X

X

X

 Adherence to treatments

X

X

X

X

X

Intervention

 Experimental or usual care treatment

 Complete self-management