Fig. 3
Change pre- and post-doxorubicin in left ventricular fractional shortening (A) according to intervention groups, there is a significant time effect (p < 0.001); (B) according to exercise compliance, there is a significant (p = 0.045) time*compliance interaction and a significant time effect (p < 0.001). *P < 0.05, **P < 0.01, represents Bonferroni corrected post hoc for time effect per group. Each circle represents a mouse. Representative M-mode images are displayed. C, compliant (n = 12); G1, HIIE day 1 post-DOX (n = 7); G2, HIIE day 2 post-DOX (n = 7); G3, HIIE day 3 post-DOX (n = 8); LVFS, left ventricular fractional shortening; N-C, non-compliant (n = 10) and SED, no exercise (n = 6)