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Table 1 Characteristics of included studies

From: Bovine colostrum supplementation and upper respiratory symptoms during exercise training: a systematic review and meta-analysis of randomised controlled trials

Study (country)

Sample size

Age, years

Proportion of males

Inclusion criteria

Exclusion criteria

Intervention, dose, frequency/timing, duration, diluter

Placebo

Crooks et al. 2006 [16]

(New Zealand)

BC: 18

PLA: 17

Median (range)

BC: males, 46 (35–57),

  females, 43 (30–53)

0.48

Pack runs ≥ 1 week, marathon training over last 5 years, age < 60 year

Lactose intolerant, allergy to cows milk, whey-protein supplements, treatment for any diagnosed condition

Oral BC (Immulac, NZMP Ltd, Auckland, New Zealand), 26 g of powdered sachets/day corresponding to 10 g of BC, daily, 12 weeks, chocolate powder with 125 ml water

Skim milk matched for equivalent digestible protein content. Flavours and colours added to match BC

PLA: males, 48 (36–56)

  females, 51 (41–58)

Crooks et al. 2010 [17]

(New Zealand)

BC: 12

PLA: 13

Mean ± standard error

BC: males, 17 ± 1

  females, 20 ± 1

0.57

Participating in training program prior to The Auckland Swimming Championships

Lactose intolerant, allergy to cows milk, whey-protein, immunological-modulating supplements, treatment for any diagnosed condition

Oral BC (Immulac, NZMP Ltd, Auckland, New Zealand), 52 g of powdered sachets/day corresponding to 20 g of BC, 10 g morning & evening, 10 weeks, 125 ml water

Skim milk powder, matched for equivalent protein, fat and carbohydrate content

PLA: males, 19 ± 1,

  females, 18 ± 1

Jones et al. 2014 [14]

(Wales)

BC: 25

PLA: 28

Mean ± standard deviation

BC: 31 ± 14

PLA: 32 ± 13

1.00

≥3 h moderate-vigorous endurance exercise/week

Smoker, medication or other supplements, infectious illness in 4 weeks prior to study

Oral BC (Neovite, UK, London), 20 g/day, 10 g with morning & evening meal, 12 weeks

Isoenergetic/isomacronutrient PLA as described elsewhere

Shing et al. 2007 [18]

(Australia)

BC: 14

PLA: 15

Mean ± standard error

BC: 29 ± 1

PLA: 27 ± 2

1.00

Cyclists racing competitively ≥ 2 months, consistent training volumes ≥ 2 months

Dietary supplements 1 month prior to study

Oral BC (Numico Research Australia, South Australia, Australia), 10 g/day, morning, 8 week 1 day, 50 ml water + 100 ml milk

Whey protein (Alacen 80; Fonterra Co-op group Limited, Auckland, New Zealand)

Shing et al. 2013 [19]

(Australia)

BC: 4

PLA: 6

Mean ± standard error 

BC: 22 ± 3

PLA: 23 ± 2

1.00

Cyclists racing competitively ≥3 months. Consistent training volumes ≥ 2 months

None reported

Oral BC (Numico Research Australia, South Australia, Australia), 10 g/day, morning, 8 weeks and 5 days, 50 ml water + 100 ml milk

Whey protein concentrate (Alacen 80; Fonterra Co-op group Limited, Auckland, New Zealand)

  1. BC bovine colostrum, PLA placebo