Tortora GJ, Derrickson B. Principles of anatomy and physiology. 14th ed. United States of America: John Wiley & Sons, Inc.; 2014.
Weeks KL, McMullen JR. The athlete’s heart vs. the failing heart: can signaling explain the two distinct outcomes? Physiology (Bethesda). 2011;26:97–105.
Ellison GM, Waring CD, Vicinanza C, Torella D. Physiological cardiac Remodelling in response to endurance exercise training: cellular and molecular mechanisms. Heart. 2012;98:5–10.
Bernardo BC, Weeks KL, Pretorius L, McMullen JR. Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacol Ther. 2010;128:191–227.
Maron BJ, Pelliccia A. The heart of trained athletes : cardiac remodeling and the risks of sports, including Suddent death. Circulation. 2006;114:1633–44.
Maron BJ, Pelliccia A, Spataro A, Granata M. Reduction in left ventricular wall thickness after deconditioning in highly trained Olympic athletes. Br Heart J. 1993;69:125–8.
Pelliccia A, Maron BJ, De Luca R, Di Paolo FM, Spataro A, Culasso F. Remodeling of left ventricular hypertrophy in elite athletes after long-term deconditioning. Circulation. 2002;105:944–9.
Nystoriak MA, Bhatnagar A. Cardiovascular effects and benefits of exercise. Frontiers in Cardiovascular Medicine. 2018;5:135.
Bernardo BC, ], Ooi JYY, Weeks KL, Patterson NL, McMullen JR. Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts. Physiol Rev 2018;98:419–475.
Lee CH, Inoki K, Guan KL. mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol. 2007;47:443–67.
Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017;168:960–76.
Sciarretta S, Forte M, Frati G, Sadoshima J. New insights into the role of mTOR signaling in the cardiovascular system. Circ Res. 2018;122:489–505.
Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011;147:728–41.
Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem. 2006;281:29776–87.
Xie M, Kong Y, Tan W, May H, Battiprolu PK, Pedrozo Z, et al. Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy. Circulation. 2014;129:1139–51.
He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012;481:511–5.
Lee Y, Kang EB, Kwon I, Cosio-Lima L, Cavnar P, Javan GT. Cardiac Kinetophagy coincides with activation of anabolic signaling. Med Sci Sports Exerc. 2016;48:219–26.
Ogura Y, Iemitsu M, Naito H, Kakigi R, Kakehashi C, Maeda S, et al. Single bout of running exercise changes LC3-II expression in rat cardiac muscle. Biochem Biophys Res Commun. 2011;414:756–60.
Fiuza-Luces C, Delmiro A, Soares-Miranda L, González-Murillo Á, Martínez-Palacios J, Ramírez M, et al. Exercise training can induce cardiac autophagy at end-stage chronic conditions: insights from a graft-versus-host-disease mouse model. Brain Behav Immun. 2014;39:56–60.
Council NR. Guide for the Care and Use of Laboratory Animals. 8th edition ed. Washington (DC): National Academies Press (US); 2011. p. 246.
Lesmana R, Iwasaki T, Iizuka Y, Amano I, Shimokawa N, Koibuchi N. The change in thyroid hormone signaling by altered training intensity in male rat skeletal muscle. Endocr J. 2016;63:727–38.
Tarawan VM, Gunadi JW, Setiawan LR, Goenawan H, Meilina DE, et al. Alteration of autophagy gene expression by different intensity of exercise in gastrocnemius and soleus muscles of Wistar rats. J Sports Sci Med. 2019;18:146–54.
Association AVM. AVMA guidelines for the euthanasia of animals: 2013 Edition; 2013. p. 1–102.
McLeod CJ, Bos JM, Theis JL, Edwards WD, Gersh BJ, Ommen SR, et al. Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations. Am Heart J. 2009;158:799–805.
Maron BJ, Wolfson JK, Roberts WC. Relation between extent of cardiac muscle cell disorganization and left ventricular wall thickness in hypertrophic cardiomyopathy. Am J Cardiol. 1992;70:785–90.
Grabner A, Amaral AP, Schramm K, Singh S, Sloan A, Yanucil C, et al. Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy. Cell Metab. 2015;22:1020–32.
Krusen M, Keyhani-Nejad F, Isken F, Nitz B, Kretschmer A, Reischl E, et al. High-fat diet during mouse pregnancy and lactation targets GIP-regulated metabolic pathways in adult male offspring. Diabetes. 2016;65:574–84.
Yin P, Wan C, He S, Xu X, Liu M, Song S, et al. Transport stress causes damage in rats' liver and triggers liver autophagy. Bio Technology : An Indian Journal. 2013;8:1561–6.
Kowalik MA, Perra A, Ledda-Columbano GM, Ippolito G, Piacentini M, Columbano A, et al. Induction of autophagy promotes the growth of early preneoplastic rat liver nodules. Oncotarget. 2016;7:5788–99.
Wang K, Wang F, Bao JP, Xie ZY, Chen L, Zhou BY, et al. Tumor necrosis factor α modulates sodium-activated potassium channel SLICK in rat dorsal horn neurons via p38 MAPK activation pathway. J Pain Res. 2017;10:1265–71.
Pinto AR, Ilinykh A, Ivey MJ, Kuwabara JT, D’Antoni ML, Debuque R, et al. Revisiting cardiac cellular composition. Circ Res. 2016;118:400–9.
Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, et al. C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010;143:1072–83.
Bernardo BC, McMullen JR. Molecular aspects of exercise-induced cardiac remodeling. Cardiol Clin. 2016;34:515–30.
Benito B, Gay-Jordi G, Serrano-Mollar A, Guasch E, Shi Y, Tardif JC, et al. Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training. Circulation. 2011;123:13–22.
Wang Y, Wisloff U, Kemi OJ. Animal models in the study of exercise-induced cardiac hypertrophy. Physiol Res. 2010;59:633–44.
Lee Y, Kwon I, Jang Y, Song W, Cosio-Lima LM, Roltsch MH. Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection. The Journal of Physiological Science: JPS. 2017;67:639–54.
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011;13:132–41.
Vasan RS, Larson MG, Levy D, Evans JC, Benjamin EJ. Distribution and categorization of echocardiographic measurements in relation to reference limits: the Framingham heart study: formulation of a height- and sex-specific classification and its prospective validation. Circulation. 1997;96:1863–73.
An P, Borecki IB, Rankinen T, Després JP, Leon AS, Skinner JS, et al. Evidence of major genes for plasma HDL, LDL cholesterol and triglyceride levels at baseline and in response to 20 weeks of endurance training: the HERITAGE family study. International Journals of Sport Medicine. 2005;26:414–9.
Vega RB, Konhilas JP, Kelly DP, Leinwand LA. Molecular mechanisms underlying cardiac adaptation to exercise. Cell Metab. 2017;25:1012–26.